Phase one detoxification consists of oxidation reduction and hydrolysis. Phase one detoxification is catalysed by enzymes referred to as the cytochrome P450 enzyme group or Mixed Function Oxidase enzymes MFO. These enzymes reside on the membrane system of the liver cells . Human liver cells possess the genetic code for many isoenzymes of P-450 whose synthesis can be induced upon exposure to specific chemicals. In addition to drinking lots of H20, prioritize eating foods that are full of water like fruits and vegetables. The tricyclic antidepressants, SSRIs, and BuSpar have shown some promise in helping recovering alcoholics stay sober. People with a bipolar disorder and substance dependency may find that recovery is easier if they use an antidepressant in addition to their regular mood stabilizer.